EPOETIN 4000 I.U. / 1 ML 1 VIAL

* Epoetin 4000 I.U. Sedico 1 vial / 1 ml. Alpha Recombinant Human Erythropoietin. For S.C. or I.V. injection.
* Composition:
  Alpha Recombinant Human Erythropoietin 4000 I.U. + Albumin (human) 2.5 mg / vial.
* Indications:
  – Treatment of anemia of chronic renal failure patients. including patients on dialysis.
  – Treatment of anemia in Zidovudine-treated HIV infected patients.
  – Treatment of anemia in cancer patients on chemotherapy.
  – Reduction of allogenic blood transfusion in surgery patients.
* Contraindications:
  – Uncontrolled hypertension.
  – Known hypersensitivity to mammalian-cell derived products.
  – Known hypersensitivity to human albumin.
* Dosage:
  # Chronic renal failure patients:
  – Doses over the range of 50 to 100 units / kg 3 times weekly have been shown to be safe and effective.
  – The dose should be reduced as the hematocrit approaches 36% or increases by more than 4 points in
  any 2-weeks period.
  – The dose must be individualized to maintain the hematocrit within the suggested target range.
  # Zidovudine-treated HIV infected patients:
  – The recommended starting dose is 100 units / kg as an I.V. or S.C. injection 3 times weekly and the dose
  may be increased every 4-8 weeks by 50 to 100 units / kg 3 times weekly.
  – If the hematocrit exceeds 40% the dose should be discontinued until the hematocrit drops to 36%.
  # Cancer patients on chemotherapy:
  – The recommended starting dose is 150 units / kg S.C. 3 times weekly.
  – Dose adjustment: if the response is not satisfactory, the dose can be increased up to 300 units / kg 3 times weekly.
  – If the hematocrit exceeds 40% the dose should be discontinued until the hematocrit drops to 36%.
  # Surgery patients:
  – The recommended dose is 300 units / kg / day S.C. for 10 days before surgery, on the day of surgery,
  and for 4 days after surgery.
* Keep at temp. from 2 to 8 oC. Avoid freezing and shaking.
* Produced by: SEDICO Pharmaceutical Co. – Egypt.
* Code: 6221042550016