& & 1- Megaoblastic anemia of pregnancy and lactation.
& & 2- Folate deficiency due to: inadequate intake, malabsorption syndrome, excessive utilization &&
& & increased excretion or need as in sprue.
& & 3- Macrocytic anemia not accompanied with neurological disturbances.
& & 4- Requirement of folic acid may be increased in:
& & Alcoholism, Cirrhosis, Hepatic disease, Hemolytic anemia, prolonged Diarrhea and use of oral
& & contraceptives or anticonvulasnt therapy.
& & 5- Megaloblastic anemia due to certain parasitic infections (especially Diphylloborthrum latum).
& & Folic acid should not be given in pernicious anemia, since it corrects the hematologic manifestations
& & and masks the pernicious anemia while allowing neurologic damage to progress.
* Dosage and administration:
& & Given orally except in severe intestinal malabsorption.
& & – Adults:
& & . Initial Therapy: 5-15 mg daily according to the case.
& & . Maintenance Dose: 2-5 mg daily.
& & – Children: 1-10 mg daily according to the case.