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* 30 depottablets (prolonged-release tablets). |
* Composition: Each tablet contains: Felodipine 5mg + Metoprolol succinate 47.5mg corresponding to 50mg Metoprolol tartrate. |
* Therapeutic indication: |
& Hypertension. Logimax can be used when treatment with beta-blockers or calcium antagonists |
& of the dihydropyridine type in monotherapy has not produced an adequate effect. |
* Posology and method of administration: |
– The dosage is individual. The starting dose is based on experience from earlier treatment with |
& beta-receptor blockers or calcium antagonists. The normal dosage is one Logimax prolonged |
& release tablet (5+50 mg) per day. If required, the dose may be increased to twice daily |
& The prolonged release tablet is given once daily, in the morning. The prolonged release tablet |
& may be taken on an empty stomach or together with a light meal with a low fat and carbohydrate |
& content. |
– Elderly patients: One Logimax prolonged release tablet per day is usually sufficient. If required, |
& the dose may be increased to twice daily. |
– Children: There is a lack of experience of treatment of children. |
* Contraindications: |
– Known hypersensitivity to any of the components of the product or to the other dihydropyridines or |
& beta-blockers. |
– Pregnancy. |
– Unstable angina pectoris. |
– Degree II and III AV block. |
– Patients with unstable uncompensated heart failure (pulmonary oedema, hypoperfusion or hypotension), |
& and patients with continuous or intermittent inotropic therapy with beta-receptor agonism. |
– Symptomatic bradycardia or hypotension. |
– Sick sinus syndrome. |
– Cardiogenic shock. |
– Severe peripheral vascular disease with threat of gangrene. |
– Logimax must not be given to patients with suspected acute myocardial infarction with a heart rate of |
& < 45 beats / minute, P-Q interval > 0.24 seconds or systolic blood pressure < 100 mmHg. |
* Sepcial warnings and precautions for use: |
– Combination treatment with digitalis. |
– Logimax can exacerbate the symptoms of peripheral vascular disease, e.g. intermittent claudication. |
– Severly impaired renal function (GFR < 30 mL/min). |
– Aortic stenosis. |
– Impaired hepatic function. |
– Heart failure following acute myocardial infarction. |
– Acute myocardial infarction. |