SESERINE 50 MG 30 TAB

* Indications:

– Symptoms of depression, including depression accompanied by symptoms of anxiety, in patients with or without a history of mania.

– Preventing relapse of the initial episodes of depression or recurrent episodes.

– Obsessive-compulsive disorder (OCD).

– Panic disorder with or without agoraphobia.

– Post-traumatic Stress Disorder.

* Dosage & Administration:

50 mg / day either in the morning or in the evening and could be increased gradually to 200mg/day within one week. Daily dose of 150 mg or more should not be given for longer than 8 weeks, after that the maintenance dose could be reduced to 50 mg / day. Patients with renal impairment, dosage adjustment is not necessary, while patients with hepatic impairment, a lower or less frequent dosage interval should be used.

* Contraindications:

– Hypersensitivity to Sertraline.

– Concomitant use in patients taking monoamine oxidase inhibitors (MAOIs).

* Precautions:

– Care and prudent medical judgement should be exercised. When switching from other anti-depressants or antiobsessional drugs, particularly from long-acting agents, e.g. Fluoxetine.

– Activation of mania or hypomania has been reported in 0.6% of Sertraline treated patients.

– Unstable epilepsy and patients with controlled epilepsy should be carefully monitored for seizures.

– Myocardial infarction or unstable heart disease.