TOPIRAMATE 25 MG 30 TAB

* Indications: Topiramate is indicated as monotherapy or adjunctive therapy for adults and pediatric patients with refractory
& & partial seizures with or without secondary generalization, and primary generalized tonic-clonic seizures. Topiramate is also
& & indicated as preventive migraine therapy for those suffering from recurring migraines that interfere with daily functioning
& & (more than 2 migraine per month) to decrease severity, duration and number of migraine attacks per month.
* Dosage and Administration:
& & # Epilepsy control:
& & – The initial dose of Topiramate is 50 mg once daily by mouth for one week increased thereafter by increments of 50 mg at
& & weekly intervals until the effective dose is reached, which is usually within the range of 200 to 400 mg daily taken into
& & 2 divided doses; some patients may require up to 800 mg daily. A lower initial dose, smaller increments , or longer intervals
& & between increments may be necessary if patients cannot tolerate the above regimen.
& & – The recommended dose for children aged 2-16 years is about 5 to 9 mg per kg body-weight daily in 2 divided doses.
& & Dosage is begun with 25 mg nightly for the first week and increased at intervals of 1 to 2 weeks by increments of
& & 1 to 3 mg per kg daily.
& & – Daily doses of more than 50 mg should taken in 2 divided doses. Patients with moderate to severe renal impairment
& & take longer to reach steady-state plasma concentrations than the patients with normal renal function. It has been recommended
& & that doses be halved in such patients. As with other antiepileptics, withdrawal of Topiramate therapy or transition to or from
& & another type of antiepileptic therapy should be made gradually to avoid precipitating an increase in the frequency of seizures.
& & # Migraine control:
& & Slow titration (25-50) mg / day with weekly increment by (25-50) mg and initial target dose of 100 mg / day in 2 divided doses
& & are recommended.
* PRESCRIPTION ONLY MEDICINE. To be used on medical advice.
* Store at room temperature between 15 degrees C – 30 degrees C, protect from moisture.
* Manufactured by: Sabaa International Company for Pharmaceutical && Chemical Industries.
& & Topiramate is a registered trade mark of Sabaa International Company for Pharmaceutical && Chemical Industries S.A.E.
* Code: 374959595002.